2. Signaling Pathways
  3. Epigenetics
  4. Histone Methyltransferase
  5. EHMT1/GLP/KMT1D Isoform
  6. EHMT1/GLP/KMT1D Degrader

EHMT1/GLP/KMT1D Degrader

EHMT1/GLP/KMT1D Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-141877
    MS4322
    		Degrader 99.14%
    MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )).